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Uncoupling Protein
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Ein Uncoupling Protein (β€šEntkopplungsproteinβ€˜) ist ein mitochondriales Membranprotein, das Protonen ohne chemiosmotische Kopplung durch die mitochondriale Membran lΓ€sst und somit die Atmungskette entkoppelt.cite-ref-pmid16179945-1-0[1]

Contents

β€’ Eigenschaften
β€’ Weblinks
β€’ Einzelnachweise

──────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────

Eigenschaften

In SΓ€ugetieren gibt es fΓΌnf Typen:

β€’ UCP1 (synonym Thermogenin)cite-ref-2[2]
β€’ UCP2cite-ref-3[3]
β€’ UCP3cite-ref-4[4]
β€’ SLC25A27 (synonym UCP4)cite-ref-5[5]
β€’ SLC25A14 (synonym UCP5)cite-ref-6[6]

Uncoupling Proteins dienen der Thermogenese, da die Protonen an FettsΓ€uren gebunden aus dem Inneren des Mitochondriums an der membranstΓ€ndigen ATPase vorbei ins Zytoplasma geschleust werden, um NeutralisationswΓ€rme zu erzeugen.cite-ref-7[7] Chemische Entkoppler der Atmungskette sind z. B. 2,4-Dinitrophenol,cite-ref-8[8] Carbonylcyanid m-chlorphenyl-Hydrazon (CCCP),cite-ref-9[9] MalachitgrΓΌn,cite-ref-10[10] SalicylsΓ€ure und teilweise auch EssigsΓ€ure. UCP werden durch SchilddrΓΌsenhormone, Adrenalin, Noradrenalin und Leptin induziert.cite-ref-11[11]

Weblinks

β€’ MeSH Uncoupling Protein

Einzelnachweise

cite-note-pmid16179945-11. ↑ Nedergaard J, Ricquier D, Kozak LP: Uncoupling proteins: current status and therapeutic prospects. In: EMBO Rep. 6. Jahrgang, Nr. 10, 2005, S. 917–21, doi:10.1038/sj.embor.7400532, PMID 16179945, PMC 1369193 (freier Volltext).
cite-note-22. ↑ R. K. Porter: Uncoupling protein 1: a short-circuit in the chemiosmotic process. In: Journal of bioenergetics and biomembranes. Band 40, Nummer 5, Oktober 2008, S. 457–461, doi:10.1007/s10863-008-9172-8. PMID 18958609.
cite-note-33. ↑ S. Diano, T. L. Horvath: Mitochondrial uncoupling protein 2 (UCP2) in glucose and lipid metabolism. In: Trends in Molecular Medicine. Band 18, Nummer 1, Januar 2012, S. 52–58, doi:10.1016/j.molmed.2011.08.003. PMID 21917523.
cite-note-44. ↑ M. Nabben, J. Hoeks: Mitochondrial uncoupling protein 3 and its role in cardiac- and skeletal muscle metabolism. In: Physiology & behavior. Band 94, Nummer 2, Mai 2008, S. 259–269, doi:10.1016/j.physbeh.2007.11.039. PMID 18191161.
cite-note-55. ↑ P. W. Ho, J. W. Ho, H. M. Tse, D. H. So, D. C. Yiu, H. F. Liu, K. H. Chan, M. H. Kung, D. B. Ramsden, S. L. Ho: Uncoupling protein-4 (UCP4) increases ATP supply by interacting with mitochondrial Complex II in neuroblastoma cells. In: PLOS ONE. Band 7, Nummer 2, 2012, S. e32810, doi:10.1371/journal.pone.0032810. PMID 22427795. PMC 3303587 (freier Volltext).
cite-note-66. ↑ P. W. Ho, A. C. Chu, K. H. Kwok, M. H. Kung, D. B. Ramsden, S. L. Ho: Knockdown of uncoupling protein-5 in neuronal SH-SY5Y cells: Effects on MPP+-induced mitochondrial membrane depolarization, ATP deficiency, and oxidative cytotoxicity. In: Journal of neuroscience research. Band 84, Nummer 6, 2006, S. 1358–1366, doi:10.1002/jnr.21034. PMID 16941493.
cite-note-77. ↑ P. Jezek, M. Jab?rek, K. D. Garlid: Channel character of uncoupling protein-mediated transport. In: FEBS letters. Band 584, Nummer 10, 2010, S. 2135–2141, doi:10.1016/j.febslet.2010.02.068. PMID 20206627. PMC 3617986 (freier Volltext).
cite-note-88. ↑ Y. Jin, M. L. McEwen, S. A. Nottingham, W. F. Maragos, N. B. Dragicevic, P. G. Sullivan, J. E. Springer: The mitochondrial uncoupling agent 2,4-dinitrophenol improves mitochondrial function, attenuates oxidative damage, and increases white matter sparing in the contused spinal cord. In: Journal of neurotrauma. Band 21, Nummer 10, Oktober 2004, S. 1396–1404, PMID 15672630.
cite-note-99. ↑ K. Kaila, K. Mattsson, J. Voipio: Fall in intracellular pH and increase in resting tension induced by a mitochondrial uncoupling agent in crayfish muscle. In: The Journal of physiology. Band 408, Januar 1989, S. 271–293, PMID 2778730. PMC 1190403 (freier Volltext).
cite-note-1010. ↑ G. Werth, A. Boiteux: Toxicity of triphenylmethane dyes. Malachite green as an uncoupling agent of oxidative phosphorylation in vivo and in vitro. In: Archiv fΓΌr Toxikologie. Band 23, Nummer 2, 1968, S. 82–103, PMID 4299566.
cite-note-1111. ↑ Gong DW, He Y, Karas M, Reitman M: Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, Ξ²3-adrenergic agonists, and leptin. In: J Biol Chem. 272. Jahrgang, Nr. 39, 1997, S. 24129–24132, doi:10.1074/jbc.272.39.24129 (jbc.org).

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